Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety\nof therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract\ncontaining baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase\nenzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro. Flavocoxid downregulates gene\nor protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models.\nControlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the\nsigns and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than\nnaproxen. Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.
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